Faculty
1. | Name | Dr. (Mrs.) Ritu Barthwal |
Designation | Professor | |
Degree | M.Sc. Hons School (Physics), Panjab Univeristy, Chandigarh (1972); Ph.D. (Physics) Indian Institute of Technology, Delhi (1976). | |
Specialization | Molecular Biophysics/Structural Biology | |
Area of Research | The research is broadly focussed on Protein-Nucleic Acid and DrugNucleic Acid Interactions by using Nuclear Magnetic Resonance (NMR) spectroscopic method, theoretical potential energy calculations and Three-dimensional molecular modeling using computer graphics. The interactions of Trp, Tyr, Phe containing oligopeptides with polyribonucleic acids, deoxyoligonucleotides e.g. d-CpG, d-CGCG, dGCGC, d-GpC, etc. as models for protein-nucleic acid interactions; hexapeptide Lys-Pro-Tyr-Ser-Leu-Asn comprising of residues 24-29 in the binding loop of the protein encoded by gene 5 of bacteriophage fd with single stranded deoxypenta adenylate and duplex d(GACTCGTC)2 containing a bulge loop; and the anticancerous antibiotic drugs daunomycin & adriamycin with deoxyoligo nucleotides d-CGATCG, d-TGATCA, d-CpG; etc. have been investigated. The emphasis is on energetics of binding, base sequence specificity, stacking and intercalation, changes in conformation of peptide/drug/DNA due to binding and their implications in structure conformation - function. Processing and simulation of NMR data is done by using FELIX, SPHINX, LINSHA, while molecular modeling by using X- PLOR, INSIGHT II and DISCOVER (M/S Molecular Simulations Incorporated, California) softwares is in progress. Drug-designing based on structural considerations is being attempted. Research collaboration with Chemical Physics group and National High Field NMR facility, Tata Institute of Fundamental Research, Mumbai (Bombay) has been established. | |
rbi@rurkiu.ernet.in |
2. | Name | Dr. G.S.Randhawa |
Designation | Professor | |
Degree | M.Sc. (Genetics) Panjab Agriculture Univeristy, Ludhiana Ph.D. (Genetics) Panjab Agriculture Univeristy, Ludhiana | |
Specialization | Genetics/Recombinant DNA Technology/ Microbial technology/Molecular Genetics of Nitrogen fixation in Rhizobium. | |
Area of Research | Genetic and biochemical studies are being carried out on the biosynthesis of amino acids, nucleotide bases and vitamins in Rhizobium meliloti. The genes involved in the above processes are characterized by transposon mutagenesis, plasmid-mediated mapping, screening of cosmid libraries, etc. The role of these genes in symbiosis is explored by plant tests with mutant R. meliloti strains Ultrastructural and biochemical analysis of the nodules formed is carried out. Research work is also in progress to understand the molecular genetics of stress tolerance in Rhizobium. | |
saran@rurkiu.ernet.in |
3. | Name | Dr. BEN. M.J.PEREIRA |
Designation | Assistant Professor & Head of the Department | |
Degree | M.Sc. (Zoology, University of Madras, Madras) M.Phil (Endocrinology, University of Madras, Madras) Ph.D. (University of Madras, Madras) | |
Specialization | Animal Physiology (Endocrinology) | |
Area of Research | Reproductive Endocrinology
Research is centred around the molecules that regulate fertility. Using goat as the animal model efforts are being made to identify the proteins/glycoproteins on the surface of sperm and egg that interact to bring about gamete recognition, binding and fertilization. In this regard, special attention is being devoted to GPI-anchored proteins on the surface of sperm and the zona antigens of egg. The synthesis and processing of GPI-anchored proteins of sperm is being studied in isolated testicular germ cells at various stage of development. The role of hormones in the expression of these proteins is also being investigated in short term cultures of germ cells. Research Collaborations : National
International: |
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pereira@rurkiu.ernet.in |
4. | Name | Dr. Vinay Sharma |
Designation | Assistant Professor | |
Degree | M.Sc. (Botany, Meerut University, Meerut), M.Phil (Meerut University, Meerut) Ph.D. (Meerut University, Meerut) | |
Specialization | Plant Physiology | |
Area of Research | Broadly current research efforts are directed on the molecular and biochemical characterization of membrane bound ATPases of groundnut seedlings. Further studies on the behaviour of these enzymes in response to a) stress both nutrient and environmental, and b) pesticide treatment; their interaction with phytohormones and isolation of their mRNA are either planned or are currently carried out. | |
biost@rurkiu.ernet.in |
5. | Name | Dr. R.P.Singh |
Designation | Assistant Professor | |
Degree | M.Sc. (Biochemistry, G.B.Pant University, Pant Nagar) Ph.D. (Kanpur University, Kanpur) | |
Specialization | Microbiology | |
Area of Research | Microbial transformation of sterols - Oral Cancer antigens Microbial cellulases. | |
rpsbs@rurkiu.ernet.in |
6. | Name | Dr. R. Prasad |
Designation | Lecturer | |
Degree | M.Sc. (Biochemistry, Banaras Hindu University, Varanasi) Ph.D. (Jawaharlal Nehru University, New Delhi) | |
Specialization | Molecular Biology | |
Area of Research |
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biost@rurkiu.ernet.in |
7. | Name | Dr. R.P.Mathur |
Designation | Professor, G.B. Pant Chair | |
Degree | M.Sc. (Zoology, Delhi University, 1956) Ph.D. (Delhi University, 1964) | |
Specialization | Environmental Science/Microbiology/Ecology | |
Area of Research | Environmental Pollution Abatement. In the current area of research emphasis is laid on use of microbial agents (fungus, yeast and bacteria) in degradation of refractory recalcitrant materials. The materials being targetted are Lignocellulosic Compounds, dyes in textile industries and Cdor (melaonidin) is distillery wastes. | |
biost@rurkiu.ernet.in |